According to WHO data, the annual number of reported cases and the estimated annual incidence rate of dengue have remained above 200,000 and 10 per 100,000, respectively, in Southeast Asia, since 2001 1. In 2019, the World Health Organization (WHO) listed dengue as one of 10 potentially threatening diseases. It is endemic in subtropical and tropical regions worldwide. Meanwhile, shifts in genotypes, rather than in serotypes, might have caused dengue epidemics in Guangzhou.ĭengue fever is caused by the mosquito-borne dengue virus (DENV). The epidemiological characteristics and phylogeny of dengue in Guangzhou suggested that although it has circulated in Guangzhou for decades, it has not been endemic in Guangzhou.
Different serotypes underwent genotype and sublineage shifts. Serotype 1 remained prevalent for most of the study period, whereas serotypes 3 and 4 were prevalent in 20, respectively. Surveillance identified four serotypes responsible for dengue infections in Guangzhou. Unlike other areas in which dengue is endemic, the infection risk in Guangzhou increased with age. There was no statistical difference in the risk of dengue infection between males and females. Dengue virus isolates from patient sera were sequenced, and phylogenetic trees were constructed using PhyML 3.1. Demographic data on 44,385 dengue cases reported to the Notifiable Infectious Disease Report System were analyzed using IBM SPSS Statistics v.
The demographic information regarding dengue cases, and the genomic characteristics of the envelope gene of dengue viruses, as well as the associations between these factors were investigated from 2010 to 2019, to improve the understanding of the epidemiology of dengue in Guangzhou. With a long epidemic history and a large number of dengue cases, Guangzhou is a key city for controlling dengue in China.
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